Project TIPS (TMS-Induced Plasticity of the Synapse)

About the Study 

Transcranial Magnetic Stimulation (TMS) has revolutionized the treatment of depression and other brain disorders, but we do not understand how it produces these lasting changes. We are using pharmacology with neurophysiology in healthy humans to determine how biochemical pathways in the brain are changed by TMS. You are invited to participate in this study because you are a healthy adult with no active psychiatric or neurologic disorders and not taking medications that impact brain excitability. 

Study Aim:

To inform TMS research through understanding how TMS changes the brain in a therapeutic and lasting way by investigating TMS-Induced Plasticity of the Synapse (TIPS).

Eligibility Requirements  

• 18 - 55 years old
• Currently medically healthy
• No history of psychiatric illness
• No history of seizure or traumatic brain injury
• No implanted metal in head/neck (except dental)
• Not taking any prescribed medications daily

Phase 0: Participants will be compensated up to $200, for ~8 hours of participation (total) during 3 study visits.

Phase 1A: Participants will be compensated up to $400, for ~15 hours of participation (total) during 5 study visits.

Location of Research

Butler Neuromodulation Research Facility 
Delmonico Building, First Floor (D1A)
Butler Hospital
345 Blackstone Blvd 
Providence, RI 02906

Contact

Jamie Kweon

Butler Hospital

(401)-680-4143

Principal Investigator

Joshua Brown, MD, PhD

Brown University Department of Psychiatry